High Level Calcineurin Activity Predisposes Neuronal Cells to Apoptosis
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چکیده
منابع مشابه
Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis.
In cyanide-induced apoptosis, an increase in cytosolic free Ca2+ and generation of reactive oxygen species are initiation stimuli for apoptotic cell death. Previous studies have shown that cyanide-stimulated translocation of Bax (Bcl-associated X protein) to mitochondria is linked with release of cytochrome c and subsequent activation of a caspase cascade [Shou, Li, Prabhakaran, Borowitz and Is...
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~e artment o Neurobiology and Anatomy, Wake Forest University School of d Meicine, Me ical Center Boulevard, Winston-Salem, NC 27157-1010, U.S., 2~omputational Neurobiology Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biolo~ical Studies, 1001 0 North Torrey Pines Road, La Jolla, CA 92037, US., '~epartm&t of Biology, University of Cali$ornia at Sun Diego, LA Jolla, CA 9209...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.48.34450